Th17 serum cytokines in relation to laboratory-confirmed respiratory viral infection: A pilot study.
Identifieur interne : 000017 ( Main/Exploration ); précédent : 000016; suivant : 000018Th17 serum cytokines in relation to laboratory-confirmed respiratory viral infection: A pilot study.
Auteurs : Emmanouil Antalis [Grèce] ; Aris Spathis [Grèce] ; Christine Kottaridi [Grèce] ; Athanasios Kossyvakis [Grèce] ; Kalliopi Pastellas [Grèce] ; Konstantinos Tsakalos [Grèce] ; Andreas Mentis [Grèce] ; Christos Kroupis [Grèce] ; Sotirios Tsiodras [Grèce]Source :
- Journal of medical virology [ 1096-9071 ] ; 2019.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Cellules Th17 (immunologie), Cytokines (immunologie), Cytokines (sang), Espagne (MeSH), Femelle (MeSH), Humains (MeSH), Infections de l'appareil respiratoire (diagnostic), Infections de l'appareil respiratoire (immunologie), Infections de l'appareil respiratoire (virologie), Interleukine-17 (sang), Interleukine-23 (sang), Interleukines (sang), Maladies virales (immunologie), Mâle (MeSH), Projets pilotes (MeSH), Sujet âgé (MeSH).
- MESH :
- diagnostic : Infections de l'appareil respiratoire.
- immunologie : Cellules Th17, Cytokines, Infections de l'appareil respiratoire, Maladies virales.
- sang : Cytokines, Interleukine-17, Interleukine-23, Interleukines.
- virologie : Infections de l'appareil respiratoire.
- Adulte, Adulte d'âge moyen, Espagne, Femelle, Humains, Mâle, Projets pilotes, Sujet âgé.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Cytokines (blood), Cytokines (immunology), Female (MeSH), Humans (MeSH), Interleukin-17 (blood), Interleukin-23 (blood), Interleukins (blood), Male (MeSH), Middle Aged (MeSH), Pilot Projects (MeSH), Respiratory Tract Infections (diagnosis), Respiratory Tract Infections (immunology), Respiratory Tract Infections (virology), Spain (MeSH), Th17 Cells (immunology), Virus Diseases (immunology).
- MESH :
- chemical , blood : Cytokines, Interleukin-17, Interleukin-23, Interleukins.
- chemical , immunology : Cytokines.
- geographic : Spain.
- diagnosis : Respiratory Tract Infections.
- immunology : Respiratory Tract Infections, Th17 Cells, Virus Diseases.
- virology : Respiratory Tract Infections.
- Adult, Aged, Female, Humans, Male, Middle Aged, Pilot Projects.
Abstract
BACKGROUND
Th17 cytokines are associated with modulation of inflammation and may be beneficial in clearing influenza infection in experimental models. The Th17 cytokine profile was evaluated in a pilot study of respiratory virus infections.
METHODS
Consecutive patients with symptoms of respiratory tract infection visiting the emergency department of a tertiary care hospital during the winter influenza season of 2014 to 2015 were evaluated. CLART PneumoVir kit, (GENOMICA, Madrid, Spain) was used for viral detection of all known respiratory viruses. Th17 cytokine profile was evaluated with the MILLIPLEX MAP Human TH17 Magnetic Bead Panel (Millipore Corp., Billerica, MA). Correlation of the TH17 profile with viral detection was performed with univariate and multivariate analysis.
RESULTS
Seventy-six patients were evaluated (median age 56 years, 51.3% female); a respiratory virus was identified in 60 (78.9%) patients; 45% had confirmed influenza. Influenza A (H3N2) correlated with higher levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 1β (IL-1β), IL-17A, IL-17E, IL-17F, IL-21, IL-22, and IL-23 (P < 0.05 by analysis of variance [ANOVA]) compared with respiratory syncytial virus (RSV). Parainfluenza virus (PIV) similarly had higher levels of GM-CSF, IL-1b, IL-17A, IL-22 compared with those detected in RSV, influenza B and any other virus infection ( P < 0.05; ANOVA). Increasing age (β-coefficient = 1.11, 95% CI, 1.04-1.2, P < 0.01) as well as IL-17A levels (β-coefficient = 1.03, 95% CI, 1.001-1.05, P = 0.04) predicted hospital admission.
CONCLUSION
Main Th17 cell effector cytokines were upregulated in laboratory-confirmed A(H3N2) influenza and PIV. Excessive amounts of Th17 cytokines may be implicated in the pathogenesis and immune control of acute influenza and PIV infection in humans and may predict the severity of disease.
DOI: 10.1002/jmv.25406
PubMed: 30715745
PubMed Central: PMC7166444
Affiliations:
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(région)</region></placeName></affiliation></author><author><name sortKey="Spathis, Aris" sort="Spathis, Aris" uniqKey="Spathis A" first="Aris" last="Spathis">Aris Spathis</name><affiliation wicri:level="3"><nlm:affiliation>2nd Department of Pathology, University of Athens Medical School, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>2nd Department of Pathology, University of Athens Medical School, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Kottaridi, Christine" sort="Kottaridi, Christine" uniqKey="Kottaridi C" first="Christine" last="Kottaridi">Christine Kottaridi</name><affiliation wicri:level="3"><nlm:affiliation>2nd Department of Pathology, University of Athens Medical School, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>2nd Department of 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last="Pastellas">Kalliopi Pastellas</name><affiliation wicri:level="3"><nlm:affiliation>4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>4th Department of Internal Medicine, University of Athens Medical School, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Tsakalos, Konstantinos" sort="Tsakalos, Konstantinos" uniqKey="Tsakalos K" first="Konstantinos" last="Tsakalos">Konstantinos Tsakalos</name><affiliation wicri:level="3"><nlm:affiliation>4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>4th Department of Internal Medicine, University of Athens Medical School, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Mentis, Andreas" sort="Mentis, Andreas" uniqKey="Mentis A" first="Andreas" last="Mentis">Andreas Mentis</name><affiliation wicri:level="3"><nlm:affiliation>National Influenza Reference Laboratory for Southern Greece, Hellenic Pasteur Institute, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>National Influenza Reference Laboratory for Southern Greece, Hellenic Pasteur Institute, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Kroupis, Christos" sort="Kroupis, Christos" uniqKey="Kroupis C" first="Christos" last="Kroupis">Christos Kroupis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Biochemistry, University of Athens Medical School, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Clinical Biochemistry, University of Athens Medical School, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Tsiodras, Sotirios" sort="Tsiodras, Sotirios" uniqKey="Tsiodras S" first="Sotirios" last="Tsiodras">Sotirios Tsiodras</name><affiliation wicri:level="3"><nlm:affiliation>4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>4th Department of Internal Medicine, University of Athens Medical School, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author></analytic><series><title level="j">Journal of medical virology</title><idno type="eISSN">1096-9071</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Cytokines (blood)</term><term>Cytokines (immunology)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Interleukin-17 (blood)</term><term>Interleukin-23 (blood)</term><term>Interleukins (blood)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pilot Projects (MeSH)</term><term>Respiratory Tract Infections (diagnosis)</term><term>Respiratory Tract Infections (immunology)</term><term>Respiratory Tract Infections (virology)</term><term>Spain (MeSH)</term><term>Th17 Cells (immunology)</term><term>Virus Diseases (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Cellules Th17 (immunologie)</term><term>Cytokines (immunologie)</term><term>Cytokines (sang)</term><term>Espagne (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Infections de l'appareil respiratoire (diagnostic)</term><term>Infections de l'appareil respiratoire (immunologie)</term><term>Infections de l'appareil respiratoire (virologie)</term><term>Interleukine-17 (sang)</term><term>Interleukine-23 (sang)</term><term>Interleukines (sang)</term><term>Maladies virales (immunologie)</term><term>Mâle (MeSH)</term><term>Projets pilotes (MeSH)</term><term>Sujet âgé (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cytokines</term><term>Interleukin-17</term><term>Interleukin-23</term><term>Interleukins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections de l'appareil respiratoire</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules Th17</term><term>Cytokines</term><term>Infections de l'appareil respiratoire</term><term>Maladies virales</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Respiratory Tract Infections</term><term>Th17 Cells</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Cytokines</term><term>Interleukine-17</term><term>Interleukine-23</term><term>Interleukines</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pilot Projects</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Espagne</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Projets pilotes</term><term>Sujet âgé</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Th17 cytokines are associated with modulation of inflammation and may be beneficial in clearing influenza infection in experimental models. The Th17 cytokine profile was evaluated in a pilot study of respiratory virus infections.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Consecutive patients with symptoms of respiratory tract infection visiting the emergency department of a tertiary care hospital during the winter influenza season of 2014 to 2015 were evaluated. CLART PneumoVir kit, (GENOMICA, Madrid, Spain) was used for viral detection of all known respiratory viruses. Th17 cytokine profile was evaluated with the MILLIPLEX MAP Human TH17 Magnetic Bead Panel (Millipore Corp., Billerica, MA). Correlation of the TH17 profile with viral detection was performed with univariate and multivariate analysis.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Seventy-six patients were evaluated (median age 56 years, 51.3% female); a respiratory virus was identified in 60 (78.9%) patients; 45% had confirmed influenza. Influenza A (H3N2) correlated with higher levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 1β (IL-1β), IL-17A, IL-17E, IL-17F, IL-21, IL-22, and IL-23 (P < 0.05 by analysis of variance [ANOVA]) compared with respiratory syncytial virus (RSV). Parainfluenza virus (PIV) similarly had higher levels of GM-CSF, IL-1b, IL-17A, IL-22 compared with those detected in RSV, influenza B and any other virus infection ( P < 0.05; ANOVA). Increasing age (β-coefficient = 1.11, 95% CI, 1.04-1.2, P < 0.01) as well as IL-17A levels (β-coefficient = 1.03, 95% CI, 1.001-1.05, P = 0.04) predicted hospital admission.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Main Th17 cell effector cytokines were upregulated in laboratory-confirmed A(H3N2) influenza and PIV. Excessive amounts of Th17 cytokines may be implicated in the pathogenesis and immune control of acute influenza and PIV infection in humans and may predict the severity of disease.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30715745</PMID><DateCompleted><Year>2020</Year><Month>03</Month><Day>26</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-9071</ISSN><JournalIssue CitedMedium="Internet"><Volume>91</Volume><Issue>6</Issue><PubDate><Year>2019</Year><Month>06</Month></PubDate></JournalIssue><Title>Journal of medical virology</Title><ISOAbbreviation>J. Med. Virol.</ISOAbbreviation></Journal><ArticleTitle>Th17 serum cytokines in relation to laboratory-confirmed respiratory viral infection: A pilot study.</ArticleTitle><Pagination><MedlinePgn>963-971</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/jmv.25406</ELocationID><Abstract><AbstractText Label="BACKGROUND">Th17 cytokines are associated with modulation of inflammation and may be beneficial in clearing influenza infection in experimental models. The Th17 cytokine profile was evaluated in a pilot study of respiratory virus infections.</AbstractText><AbstractText Label="METHODS">Consecutive patients with symptoms of respiratory tract infection visiting the emergency department of a tertiary care hospital during the winter influenza season of 2014 to 2015 were evaluated. CLART PneumoVir kit, (GENOMICA, Madrid, Spain) was used for viral detection of all known respiratory viruses. Th17 cytokine profile was evaluated with the MILLIPLEX MAP Human TH17 Magnetic Bead Panel (Millipore Corp., Billerica, MA). Correlation of the TH17 profile with viral detection was performed with univariate and multivariate analysis.</AbstractText><AbstractText Label="RESULTS">Seventy-six patients were evaluated (median age 56 years, 51.3% female); a respiratory virus was identified in 60 (78.9%) patients; 45% had confirmed influenza. Influenza A (H3N2) correlated with higher levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 1β (IL-1β), IL-17A, IL-17E, IL-17F, IL-21, IL-22, and IL-23 (P < 0.05 by analysis of variance [ANOVA]) compared with respiratory syncytial virus (RSV). Parainfluenza virus (PIV) similarly had higher levels of GM-CSF, IL-1b, IL-17A, IL-22 compared with those detected in RSV, influenza B and any other virus infection ( P < 0.05; ANOVA). Increasing age (β-coefficient = 1.11, 95% CI, 1.04-1.2, P < 0.01) as well as IL-17A levels (β-coefficient = 1.03, 95% CI, 1.001-1.05, P = 0.04) predicted hospital admission.</AbstractText><AbstractText Label="CONCLUSION">Main Th17 cell effector cytokines were upregulated in laboratory-confirmed A(H3N2) influenza and PIV. Excessive amounts of Th17 cytokines may be implicated in the pathogenesis and immune control of acute influenza and PIV infection in humans and may predict the severity of disease.</AbstractText><CopyrightInformation>© 2019 Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Antalis</LastName><ForeName>Emmanouil</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spathis</LastName><ForeName>Aris</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>2nd Department of Pathology, University of Athens Medical School, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kottaridi</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>2nd Department of Pathology, University of Athens Medical School, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kossyvakis</LastName><ForeName>Athanasios</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>National Influenza Reference Laboratory for Southern Greece, Hellenic Pasteur Institute, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pastellas</LastName><ForeName>Kalliopi</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsakalos</LastName><ForeName>Konstantinos</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mentis</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>National Influenza Reference Laboratory for Southern Greece, Hellenic Pasteur Institute, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kroupis</LastName><ForeName>Christos</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Clinical Biochemistry, University of Athens Medical School, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsiodras</LastName><ForeName>Sotirios</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0002-0463-4321</Identifier><AffiliationInfo><Affiliation>4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate 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